Hairloss Study Abstract: Topical spironolactone reduces sebum secretion rates in young adults.

Hairloss Study Abstract: Topical spironolactone reduces sebum secretion rates in young adults.

Title: Topical spironolactone reduces sebum secretion rates in young adults.
Title Abreviation: J Dermatol		Date of Pub: 1996 Apr
Author: Yamamoto A; Ito M;
Issue/Part/Supplement: 4	Volume Issue: 23		Pagination: 243-6
MESH Headings: Administration, Topical; Adult; Androgen Antagonists (AD/PD); Depression, Chemical; Human; Male; Sebaceous Glands (DE/SE); Sebum (DE/SE); Spironolactone (AD/*PD); -RN-;
Journal Title Code: HZ7	Publication Type: JOURNAL ARTICLE
Date of Entry: 961224N	Entry Month: 9702
Country: JAPAN	Index Priority: 3
Language: Eng	Unique Identifier: 97089430
Unique Identifier: 97089430	ISSN: 0385-2407
Abstract: The effects of topically applied spironolactone on the sebum secretion rates (SSR) of young adults were investigated. SSR was expressed as the ratio of wax esters/[cholesterol+cholesterol esters] (WE/[C+CE]) and the amount of sebaceous lipids (squalene, triacylglycerol and wax esters). Topical spironolactone 5% gel applied to the right cheeks of the subjects produced a significant reduction in the SSR at 12 weeks (4 weeks after termination of application), but not at 8 weeks (the end of treatment). Untreated "control" areas (the left cheeks of the subjects) showed no significant change during the study. None of the subjects experienced skin rash or signs of local irritation. This results suggests that topical spironolactone may be effective in the treatment of acne patients with high SSR.
Abstract By: Author
Address: Department of Dermatology, Niigata University School of Medicine, Japan.