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Hair Loss Study Abstract: Topical tretinoin for hair growth promotion.
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Title
Topical tretinoin for hair growth promotion.
Author
Bazzano GS, Terezakis N, Galen W
Source
J Am Acad Dermatol, 15: 4 Pt 2, 1986 Oct, 880-3, 890-3
Abstract
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil
has been tested for the promotion of hair growth in 56 subjects with androgenetic
alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted
in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate
some hair regrowth in approximately 58% of the subjects studied. One female subject with
pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a
period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation
and differentiation in the epithelium and may promote vascular proliferation. These
factors are important for hair growth promotion. These preliminary results indicate that
more work should be done on the role of retinoids in hair growth. The synergistic effect
of retinoids in combination with a low concentration of minoxidil should also be further
investigated.
Language of Publication
English
Unique Identifier
87034471
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