Stimulation of hair growth with minoxidil and a 5.alpha.-reductase inhibitor

United States Patent 5,578,599
Diani, et. al. Nov. 26, 1996

Stimulation of hair growth with minoxidil and a 5.alpha.-reductase inhibitor

Inventors: Diani; Arthur R. (Mattawan, MI); Buhl; Allen E. (Portage, MI); Schostarez; Heinrich J. (Portage, MI).
Assignee: The Upjohn Company (Kalamazoo, MI).
Appl. No.: 376,468
Filed: Jan. 20, 1995

Related U.S. Application Data

Continuation of (including streamline cont.) Ser. No. 9,451, Jan. 27, 1993, abandoned, which is a continuation of Ser. No. 565,777, Aug. 10, 1990, abandoned.
Intl. Cl. : A61K 31/505, A61K 31/44
Current U.S. Cl.: 514/275; 514/284
Field of Search: 514/284, 275

References Cited | [Referenced By:]

U.S. Patent Documents

4,139,619 Feb., 1979 Chidsey, III 424/45
4,596,812 Jun., 1986 Chidsey, III et al. 514/256
4,684,635 Aug., 1987 Orentreich et al. 514/170
5,026,691 Jun., 1991 Kligman et al. 514/171

Foreign Patent Documents

0285382A2 Oct., 1988 EP  
3615396A Nov., 1987 DE  
1305017A Dec., 1989 JP  
WO87/00427 Jan., 1987 WO  

Primary Examiner: Cintins; Marianne M.
Assistant Examiner: Moezie; M.
Attorney, Agent or Firm: Corneglio; Donald L.

Abstract

An improved method and composition for promoting hair growth in mammals for treating various forms of alopecia or male pattern baldness comprising the concomitant administration of potassium channel openers, such as minoxidil, cromakalim, pinacidil, or a compound selected frown the classes of s-triazine, thiane-1-oxide, benzopyran and pyridinopyran compounds; and a 5.alpha.-reductase inhibitors, 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one. The method comprises administering an effective amount of the potassium channel opener and administering an effective amount of the 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one whereby the promotion of hair growth is increase over the sole administration of the potassium channel opener.

4 Claims, No Drawings

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