United States Patent 5,252,559

United States Patent	5,252,559
Kronholm, et. al.	Oct. 12, 1993

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His-Gly-Gly peptide and derivatives thereof for hair growth

Inventors:	Kronholm; Kurt G. (Oxford, OH); Schwen; Richard J. (Cincinnati, OH); Sine; Mark R. (Morrow, OH); Warren; Raphael (Cincinnati, OH); Wawrzyniak; Cynthia J. (Cincinnati, OH).
Assignee:	The Procter & Gamble Company (Cincinnati, OH).
Appl. No.:	747,811
Filed:	Aug. 20, 1991

Intl. Cl.:	A61K 37/02; C07K 5/08
U.S. Cl.:	514/ 18; 530/331
Field of Search:	514/18; 530/331

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References Cited [Referenced By:]

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U.S. Patent Documents

Foreign Patent Documents

Other References

• Bachem Bioscience, Inc., Catalog US 4--1991 p. 295.

  Ueda, J., A., Hanaki, N. Yoshida and T. Nakajima-"(^1) H-Nuclear Magnetic Resonance Study of the Interaction of Zinc(II) Ion with a Histidine-Containing Peptide, L-Histidylglycylglycine," Chem. Pharm. Bull. vol. 33, pp. 3096-3100 (1985).

  Yokoyama, A., H. Aiba and H. Tanaka-"Acid Dissociation Constants of Some Histidine-Containing Peptides and Formation Constants of Thier Metal Complexes," Bulletin of the Chemical Society of Japan, vol. 47, pp. 112-117 (1974).

  Schneider, F.-"Tripeptide des Histidins," Z. Physiol. Chem., vol. 321, pp. 38-48 (1960).

  Davis, N. C.-"Action of Proteolytic Enzymes on Some Peptides and Derivatives Containing Histidine," J. Bio. Chem., vol. 223, pp. 935-947 (1956).

Primary Examiner: Lee; Lester L.
Attorney, Agent or Firm: Corstanje; Brahm J., Graff, IV; Milton B., Yetter; Jerry J.

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Abstract

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The present invention relates to a composition for regulating hair growth comprising a safe and effective amount of the tripeptide histidyl-glycyl-glycine, or a derivative thereof, and a pharmaceutically-acceptable carrier.

7 Claims, No Drawings