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17-Ethers and thioethers of 4-aza-steroids
|
| United States Patent |
5,536,727 |
| Witzel, et. al. |
Jul. 16, 1996 |
17-Ethers and thioethers of 4-aza-steroids
asteroids as 5A-reductase
inhibitors
| Inventors: |
Graham; Donald W. (Mountainside, NJ); Aster; Susan D.
(Teaneck, NJ); Hagmann; William (Westfield, NJ); Tolman; Richard L. (Warren,
NJ). |
| Assignee: |
Merck & Co., Inc. (Rahway, NJ). |
| Appl. No.: |
335,792 |
| Filed: |
Nov. 10, 1994 |
Related U.S. Application Data
| Continuation-in-part of Ser No. 886,021, May 20, 1992, abandoned. |
| Intl. Cl. : |
C07D 241/12, A61K 31/495 |
| Current U.S. Cl.: |
544/336; 544/405; 544/406; 546/77 |
| Field of Search: |
546/77; 514/284, 253; 544/336 |
References Cited | [Referenced
By:]
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|
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|
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Nov., 1993 |
WO |
|
| WO93/23420 |
Nov., 1993 |
WO |
|
- Other References
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Primary Examiner: Daus; Donald G.
Attorney, Agent or Firm: Giesser; Joanne M., Fitch; Catherine D., Winokur; Melvin
Abstract
Described are new 17.beta.-ester, amide and ketone 4-aza-5a-androstan-3-ones and
related compounds and their use as 5a-reductase inhibitors for treatment of benign
prostatic hyperplasia and other hyperandrogenetic related disorders.
3 Claims, No Drawings
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