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Hair Loss Study Abstract: Transcutaneous absorption of ketoconazole in infant after application of Ketoderm
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Title
[Transcutaneous absorption of ketoconazole in infant after application of Ketoderm]
Original Title
Passage transcutané du kétoconazole chez le nourrisson après application de Ketoderm.
Author
Levron JC; Taieb A
Address
Laboratoire de Pharmacocinétique, Laboratoires Janssen, Boulogne.
Source
Therapie, 46: 1, 1991 Jan-Feb, 29-31
Abstract
The percutaneous absorption of ketoconazole was studied in 7 infants (1 to 5 month of
age) with extensive seborrhoeic dermatitis (greater than 50% of the surface area), after
application of a 2% ketoconazole cream (Ketoderm). The plasma concentrations of
ketoconazole were measured by HPLC at the first, 5th and 10th day of the treatment.
Despite the large surface involved, plasma levels ranging, from 0.018 to 0.133
micrograms/ml were measured. These values are low, as compared with the concentrations
observed following oral administration (4 to 9 micrograms/ml), and suggest that the
occurrence of systemic dose-dependent side effects is very unlikely. A careful monitoring
of prescription remains however necessary.
Language of Publication
French
Unique Identifier
91213165
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